This species can be distinguished from related non-natives by its trailing stems and lance-shaped leaves. Stachytarpheta urticifolia, commonly sold by non-native nurseries, is native to tropical Asia. It has an erect growth habit. Groundcover or in a meadow.

Allow to climb on trellis, trees, or building masonry. The tendrils of Virginia creeper are tipped with adhesive-like disks that gives the vine the ability of cementing itself to surfaces. Unlike many vines, these tendrils will not penetrate the surface of the masonry which can be detrimental to the structure. Can be used as a ground cover.

Host plant for Zestos Skipper butterfly which is believed to be extirpated (extinct) in FLorida. Also used by Cassius blue, longtailed skipper, and Zarucco duskywing Grown by enthusiasts.