While naturally a wetland plant, this species does well across a broad array of cultural conditions. Specimen tree.

Many cultivars have been developed or found in the wild ranging from weeping forms to little round balls ('Shillings'). To get fruits, both a male and a female are required. Although there are issues with provenance, 'Shillings' is a male and can provide an inconspicuous source of pollen for larger females. The issue (with no scientifically vetted answer) is whether pollen from a natural dwarf could have any affect on wild populations of yaupon holly (the author suspects 'no' as being dwarf is unlikely to provide any selective advantage in the wild. Specimen tree.