Listed as Threatened by the Florida FDACS. Host plant for mahogony mistletoe,Phoradendron rubrum, which is listed as Endangered by the Florida FDAS. There are reports that this tree is becoming invasive in southern Florida in some areas beyond its natural range. Street tree. Yard and park shade tree.

Each stem has soft, fleshy green flanges running longitudinally down its length. When winter weather brings ice, the stems exude water that freezes into fascinating shapes, hence its common name frostweed. Background plant in a wildflower garden. Also useful as a mass planting along a forest edge. This plant is best used in informal settings and does well if allowed to naturalize.

Coral honeysuckle's bark exfoliates. Climbs by twining Given a trellis or fence this plant makes a great hedge. It can also make a good groundcover though it will not bloom as well as it does with support. Expect this plant to be evergreen in most of Florida but deciduous in colder areas.

Not salt tolerant of inundation by salty or brackish water. Low/no tolerance of salty wind or direct salt spray

It's quite hardy and tolerant of difficult environments. The herbarium specimen from Wakulla County is from a natural area.  It is a 2012 specimen and could represent a range expansion. Hedge or screen plant. Can be used on the edges of parking lots. Fairly narrow in form.

Based on BONAP maps, the ISB maps and specimens, and one author's personal observations, the range of this species appears to be those parts of the coastal plain and adjacent areas of sandhill where there are seepage wetlands.  The range extend from Mississippi to South Carolina.  It may be excluded from the southern half of the Florida peninsula temperatures unsuitable for its reproduction. This grows as a viney shrubl. Can be grown as a shrub if pruned but could also be trained against an arbor or post.