Can be used as an accent plant or grown in the mid-rear of the garden. Also suitable in wildflower gardens. Its broad tolerance of soil and moisture conditions make it a good plant for difficult places. More robust if grown in fertile soils.

To see how crossvine gets its common name, cut a mature stem and you'll see that the pith is cross-shaped. Climbs using tendrils with adhesive disks. Tall climbing vine. Works well on a trellis and can also be allowed to grow up trees. High-climbing, twining, clings by tendrils.

Although it has square stems and opposite leaves like members of the mint family (Lamiaceae), this is a member of the daisy family, but it has no ray florets that look like petals. All the florets in the flower head are fertile. Use in a butterfly garden or informal wildflower garden.