Range includes most of eastern and central north Ameria west to the prairie region and north into southeastern Canada.  The southern range limit is in the Florida panhandle. Wildflower garden, typically a shade garden.

Wetland garden including bog gardens. Natural wetland settings.

Toxic  to humans. and some animals. Specimen plant, foundation planting, screen.

To see how crossvine gets its common name, cut a mature stem and you'll see that the pith is cross-shaped. Climbs using tendrils with adhesive disks. Tall climbing vine. Works well on a trellis and can also be allowed to grow up trees. High-climbing, twining, clings by tendrils.