While it is related to chestnuts, its not generally subject to chestnut blight, and if it gets it, will likely recover. Natural settings as a small shade tree or large shrub.

There is potential name confusion with this species since it was formerly considered to be a subspecies of O. hirtellus (Oplismenus hirtellus subsp. setarius) The Florida Plant Atlas indicates that Oplismenus setarius is common in Florida. O. hirtellus (not the subspecies) has been documented from only one Florida county, and it is a non-native. This is a low groundcover that can be effective seasonally as a low-use turf in shady locations.

Naturalistic woodland landscapes.

This is a rare plant that should not be disturbed in the wild. Could be used as a border along sandy paths or walkways or as a foundation plant.

Restoration of savannas. Curiosity in the wildflower garden.

Flower color varies, which gives the plant a multi-hued array of flowers. Listed as Threatened in Florida Specimen plant where its showy, multi-colored flowers can be seen. Use as a large shrub to small tree.  Works well planted in clusters.