While it is related to chestnuts, its not generally subject to chestnut blight, and if it gets it, will likely recover. Natural settings as a small shade tree or large shrub.

Specimen plant, thicket, or natural background plantings.

There is potential name confusion with this species since it was formerly considered to be a subspecies of O. hirtellus (Oplismenus hirtellus subsp. setarius) The Florida Plant Atlas indicates that Oplismenus setarius is common in Florida. O. hirtellus (not the subspecies) has been documented from only one Florida county, and it is a non-native. This is a low groundcover that can be effective seasonally as a low-use turf in shady locations.

USF Plant Atlas location in Hillsborough appears to have been from seed in imported soil - the one in St. Lucie County has been removed from the FLAS database (likely it was an error). The Institute for Regional Conservation reports the species to be extirpated in Florida  though it is occasionally cultivated, potentially from imported plants.  Images provided here are from a specimen cultivated by Roger Hammer. Use as a specimen plant.

Retain if in the landscape. Can be used as a specimen plant in areas not subject to root disturbance.

This is a Florida endemic listed by the USFWS and the State of Florida as Endangered.  Please acquire only from reputable sources that have the proper permits. Groundcover in dry coastal settings.

Naturalistic woodland landscapes.

This is a rare plant that should not be disturbed in the wild. Could be used as a border along sandy paths or walkways or as a foundation plant.

Interesting silky-looking foliage. Tallish groundcover in mesic (moist) areas. Can be planted in groupings in shady areas. Despite the name, the leaves are pretty, almost silky or velvety in appearance.

Flower color varies, which gives the plant a multi-hued array of flowers. Listed as Threatened in Florida Specimen plant where its showy, multi-colored flowers can be seen. Use as a large shrub to small tree.  Works well planted in clusters.